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Seminar 28/4/2022

The next scientific seminars of Institute for Computational Science (INCOS) & Advanced Institute of Materials Science (AIMaS), Ton Duc Thang University, will be organized online at 9.00 AM on Thursday, 28th April 2022.

The seminars in this week (224th seminar) will include the following topics:

9.00 AM – 10.00AM: Ph.D. Candidate Cong Tran (Seoul National University of Science and Technology - SeoulTech) presents the topic: "Zebrafish: New tool for toxicological assessment" 

Abstract:

Zebrafish (Danio rerio) have been raised as a valuable model for toxicological assessment. Zebrafish may be conducted to screen the chemicals or drug toxicity in a high-throughput screening assay.  As an embryotoxicity model, zebrafish embryos are at the leading edge of toxicology studies because of various advantages including fast development, transparency of embryos, high fertility, high genetic homology, and low cost. Due to the biological environment, most of the zebrafish's toxicological studied chemicals were water solutes. This review examines the toxicological research using the zebrafish model and highlights its advantage as a valuable tool for toxicity assessment of environmental chemicals and medical drugs.

10.00 AM - 11.00AM: Mr. Dang Minh Phung (Ho Chi Minh City University of Technology and Education) presents the topic: "Optimal design and analysis for a novel 1-DOF compliant stage based on additive manufacturing method for testing medical specimens" 

Abstract:

Nano/micro-indentation testing technique is now extensively identified as the favorite approach so as to check the quality characteristics of specimens. Because surface features affect significantly in biology, particularly in bio-materials and medical specimen, there has a rising attention for applying in nano/micro-indentation tester systems. In such these systems, a miniaturized size, a fast response, and an effective computation method of the indentation should be balanced during the design and analysis phases. It means that the symmetry in designing and analyzing the mechanical systems of indentation should be remained so as to decrease a complexity of the design phase and facilitate the computation techniques. Consequently, this paper proposes a new compliant one degree of freedom (01-dof) stage to apply for such an indentation testing system. Firstly, the 1-dof stage is designed based on six-lever amplifier integrated flexure elliptical hinges and symmetric parallel guiding mechanism. Secondly, a kinetostatic diagram of the stage is built by pseudo-rigid-body model. Then, the dynamic equation of the proposed positioner is formulated using Lagrange’s principle. In order to speed up the response of the testing system, the structural parameters of the stage are optimized via the Firefly algorithm. The results showed that the theoretical first-order resonant frequency is found about 226.8458 Hz. Additionally, the theoretic consequences are nearby to the verified simulation consequences. Besides, this achieved frequency of the presented stage is greater than that of previous stages. In upcoming study, the prototype will be fabricated by additive manufacturing in order to verify the analytical results with experimental results.