Seminar khoa hoc
9.00 AM – 10.00AM: Ô. Lê Thanh Hòa (AIMaS) trình bày về: "Improving the spectrum of antibody, peptide against Hemagglutinin of Influenza A virus subtypes by grafting hotspot amino acid"
A high rate of mutation enables the Influenza A virus (IAV) to resist antibiotics previously effectively inhibitory against IAV. The molecule Hemagglutinin (HA) of IAV has a function in cellular infection and its structure is assumed to be more conserved than its gene sequence in order to maintain its biological function. This is a potential target for the development of anti-flu treatment. My study widens the spectrum of known anti-HA antibodies and peptide binding to the conserved region by grafting hotspot amino acid onto the complementarity-determining region (CDR), a method that has been successful before. First, the conserved regions were identified by structure superposition. The hotspot amino acid was found by docking 20 types of amino acids onto the conserved regions on the surface of HA and choosing the one with the lowest change in free energy. Methionine showed such characteristics and was grafted onto the CDR, resulting in an antibody and a peptide with a broader spectrum against HA from subtypes H1, H2, H3.
10.00 AM - 11.00AM: TS. Nguyễn Thị Hải Yến (Đại học công nghiệp) trình bày về: "Electrochemical chloride extraction on reinforced concrete contaminated external chloride: Efficiencies of intermittent applications and impacts on hydration products"
Corrosion of reinforced steel is one of the main causes of the deterioration of reinforced concrete structure, which lead to the short service life of structure and waste of natural resources, affecting the environmental degradation and climate change. Many methods have been proposed to rehabilitate reinforced structures. Electrochemical chloride extraction has been proven as an economic technique to rehabilitate the reinforced concrete structure that deteriorated due to chloride ion. In this method, a direct electric current is applied on the reinforced concrete structure where the steel reinforcements are connected to the cathode and an external electrode mounted on the concrete surface imposed to the anode. However, the long application time of direct current can cause several detrimental effects of the microstructure of concrete, which consequently affect the durability of structure. In this research, the proper application of electrochemical chemical extraction is proposed to alleviate these adverse effects.